48ð ڷγ19 Ű '̹ ƾ'̶?
þ Ŵ Բϼ
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̹ ƾ, Ű پ ġῡ
̹ ƾ, SARS-CoV-2 ̷ 48ð ̳ Ű Ÿ
̹ ƾ(ivermectin) ֱ 迡 ڷγ19 48ð ̳ Ű Ÿ.
̹ ƾ ڷγ19 Ű SARS-CoV-2 ̷ ִ ü 'κƮ( , in vitro)' ȯ濡 48ð ̳ ״.
̱ǰǾ౹(FDA) 㰡 ̹ ƾ 迡 ̷ 5000 ̴ Ÿ鼭 ټ ̹ ƾ ߰(repurposing) ʿ伺 ߴ.
Ȯϴ ڷγ19 , ġ
ڷγ19 Ȯڰ 127 Ѱ Ȯڵ 1 ѱ鼭 ڷγ19 ġ ĺ Ϸ ̰ ִ.
Ư ġ ̵ϽŬη, HIV ġ dz+䳪(ǰ ĮƮ), װ λ縣ź(ǰ ) ڷγ19 ġ ΰ ڷγ19 Ű Ȯ ġ ʾҴ.
̿ ȣ ξ(Royal Melbourne Hospital) 丮 (Victorian Infectious Diseases Reference Laboratory) Leon Caly 3 Antiviral Research ǥϸ鼭 ƹƾ ڷγ19 ġ ִٰ .
Caly "̹ ƾ κƮ ȯ濡 ̷ Ȱ ־ FDA ߴ" "̹ ƾ 2ð ̳ Vero-hSLAM ϸ 48ð ̳ RNA ̷ 5000 ־ ΰ ȿ ִ ʿ䰡 ִ" .
̹ ƾ̶?
̹ ƾ پ ġϴ ȴ. FDA 㰡 Ȳ ̹ƾ Ӹ, (scabies), ;(river blindness), м, , ȸ ġ.
̹ ƾ Ű ƹƾ(avermectin) 迭 Ѵ.
̹ ƾ 1975 Ϻ Ÿ Satoshi Omura Ϸ ũǻƽġ(Merck Institute for Therapeutic Research) William C. Campbell ߴ.
2015 ƹƾ ߰ θ 뺧 л ڷ ̸ ÷ȴ.
Omura ̹ ƾ Streptomyces avermitilis ƿ ĺ Campbell Omura ĺ 繰κ ̹ ƾ ߴ. ̴ ϰ ̹ƾ ߰ ̾.
̹ ƾ (endectocide), ǥ鿡 ϴ 濡 ۿ ִ . ̹ƾ 0.12 ġ ̱ 50 Ѵ.
̹ ƾ ۿ ?
̹ ƾ 1981 Ƿ Ǿǰ ǰ 躸DZⱸ(WHO) ʼ Ǿǰ (List of Essential Medicines) ߰ߴ. ó ƴ. , ȸ, ĸ, (lice) ⸦ ġϴ ֿϰ߰ ҿ ȴ.
ΰ Ȱ ̸ ġϴ ȸ(roundworm) (whipworm) Ű ġ ȴ.
̹ ƾ Ų Ų. Ư Ű迡 Ű ʰ ǵ ϸ ĵ ߰ų ˷.
Ű ۿϳ, 庮 ̹ƾ ϴ ´.
ġ ̹ ƾ?
̹ ƾ ġ߹̷, , Ͽ ġ ִٰ ִ.
ɶ Ű (University of Bonn) Į ̹ƾ ġ߹̷(chikungunya virus) ȿ ִٰ ǥ, ̱ ݷζָ Brian D Foy ̹ƾ 5 Ҿƿ ٰ ߰ߴ.
ij 긮Ƽ÷ƴ ̹ ƾ Ű Ƹ ȿ ̴ ߰ߴ. Ӹ ƴ϶ Ϻ ī ̹ ƾ ǼҾϿ Բ Ǹ ġ ȿ Ѵٰ ǥߴ.
ڷγ19 ̹ ƾ?
ڷγ19 SARS-CoV-2 ̷ Ͼ ȣı SARS-CoV ˷.
SARS-CoV ܹ IMP/1 ´. IMP/1 SARS-CoV Ŭĸõ ܹ ȣ ټ(nucleocytoplasmic shutting) ִٴ ̴. ̴ ̷ ӿ ϴ Ϳ ĥ ִٴ ûѴ.
̹ ƾ ټ۾Ȱ(nuclear transport inhibitory activity) ȿ SARS-CoV-2 ȿ ִٰ Caly ߴ. ̹ ƾ ܹ ټ(nuclear import) HIV-1 ϴ Ȯεƴ.
ڷγ19 Australia/VIC01/2020 ָ vERO/Hslam ǿ ״. ̹ ƾ ߴ.
, ̹ ƾ û 24ð ̳ RNA ̷ 93% ƴ. ̷ 99.8% Ÿ.
48ð ̹ ƾ ġ RNA ̷ 5000 پ. 72ð ̷ ̻ ʾҴ. ƴ.
"ٸ RNA ̷ ϰ IMP/1 Ű ټ(nuclear import)Ǵ ̷ ܹ ν ̹ƾ ȿ ִٴ " ߴ.
ġ ۿ?
̹ ƾ ó ϰų Ǻο ٸ ִ. 뷮 ġϴ ĸ ϸ ̻ Ͼ ִ.
ۿ , , , , , ִ.
ǰǾǰó ̹ ƾ ʾ "Ϲ ġ ߵǷ ӻ ߰ ʿϴ" .