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ۼ : 24-12-08 01:30
48ð ڷγ19 Ű '̹ ƾ'̶? - þ ulaG9.top
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48ð ڷγ19 Ű '̹ ƾ'̶?


þ Ŵ Բϼ

https://3m58.ulag9.top

̹ ƾ, Ű پ ġῡ

̹ ƾ, SARS-CoV-2 ̷ 48ð ̳ Ű Ÿ

̹ ƾ(ivermectin) ֱ 迡 ڷγ19 48ð ̳ Ű Ÿ.

̹ ƾ ڷγ19 Ű SARS-CoV-2 ̷ ִ ü 'κƮ( , in vitro)' ȯ濡 48ð ̳ ״. 

̱ǰǾ౹(FDA) 㰡 ̹ ƾ 迡 ̷ 5000 ̴ Ÿ鼭 ټ ̹ ƾ ߰(repurposing) ʿ伺 ߴ.

 

Ȯϴ ڷγ19 , ġ

ڷγ19 Ȯڰ 127 Ѱ Ȯڵ 1 ѱ鼭 ڷγ19 ġ ĺ Ϸ ̰ ִ.

Ư 󸮾 ġ ̵ϽŬη, HIV ġ dz+䳪(ǰ ĮƮ), װ λ縣ź(ǰ ) ڷγ19 ġ ΰ ڷγ19 Ű Ȯ ġ ʾҴ. 

̿ ȣ ξ(Royal Melbourne Hospital) 丮 (Victorian Infectious Diseases Reference Laboratory) Leon Caly 3 Antiviral Research ǥϸ鼭 ƹƾ ڷγ19 ġ ִٰ . 

Caly "̹ ƾ κƮ ȯ濡 ׹̷ Ȱ ־ FDA ߴ" "̹ ƾ 2ð ̳ Vero-hSLAM ϸ 48ð ̳ RNA ̷ 5000 ־ ๰ ΰ ȿ ִ ʿ䰡 ִ" . 

̹ ƾ̶?

̹ ƾ پ ġϴ ȴ. FDA 㰡 Ȳ ̹ƾ Ӹ, (scabies), ;(river blindness), м, , ȸ ġ. 

̹ ƾ Ű ƹƾ(avermectin) ๰ 迭 Ѵ. 

̹ ƾ 1975⿡ Ϻ Ÿ Satoshi Omura Ϸ ũ׶ǻƽġ(Merck Institute for Therapeutic Research) William C. Campbell ߴ. 

׵ 2015 ƹƾ ߰ θ 뺧 л ڷ ̸ ÷ȴ. 

Omura ̹ ƾ Streptomyces avermitilis ׸ƿ ĺ Campbell Omura ĺ 繰κ ̹ ƾ ߴ. ̴ ϰ ̹ƾ ߰ ̾.

̹ ƾ ׿(endectocide), ǥ鿡 ϴ 濡 ۿ ִ . ̹ƾ 󱹿 0.12 ޷ ġ ̱ 50޷ Ѵ. 

̹ ƾ ๰ ۿ ?

̹ ƾ 1981⿡ Ƿ Ǿǰ ǰ 躸DZⱸ(WHO) ʼ Ǿǰ (List of Essential Medicines) ߰ߴ. ๰ ó ƴ. ๰ , ȸ, ĸ, (lice) ⸦ ġϴ ֿϰ߰ ҿ ȴ. 

ΰ Ȱ ̸ ġϴ ȸ(roundworm) (whipworm) Ű ġ ȴ. 

̹ ƾ Ų Ų. ๰ Ư Ű迡 Ű ʰ ǵ ϸ ĵ ߰ų ˷. 

Ű ۿϳ, 庮 ̹ƾ ϴ ´. 

ġ ̹ ƾ?

̹ ƾ ġ߹̷, 󸮾, Ͽ ġ ִٰ ִ. 

ɶ Ű (University of Bonn) ޵Į ̹ƾ ġ߹̷(chikungunya virus) ȿ ִٰ ǥ, ̱ ݷζָ Brian D Foy ̹ƾ 5 Ҿƿ 󸮾 ߻ ٰ ߰ߴ.

ij 긮Ƽ÷ƴ ̹ ƾ Ű ׸Ƹ ȿ ̴ ߰ߴ. ׻Ӹ ƴ϶ Ϻ ī ̹ ƾ ǼҾϿ ׾ Բ Ǹ ġ ȿ Ѵٰ ǥߴ.

ڷγ19 ̹ ƾ?
ڷγ19 SARS-CoV-2 ̷ Ͼ ޼ȣı SARS-CoV ˷.
SARS-CoV ܹ IMP/1 ´. IMP/1 SARS-CoV Ŭĸõ ܹ ȣ ټ(nucleocytoplasmic shutting) ִٴ ̴. ̴ ̷ ӿ ϴ Ϳ ĥ ִٴ ûѴ. 
̹ ƾ ټ۾Ȱ(nuclear transport inhibitory activity) ȿ SARS-CoV-2 ȿ ִٰ Caly ߴ. ̹ ƾ ܹ ټ(nuclear import) HIV-1 ϴ Ȯεƴ.
ڷγ19 Australia/VIC01/2020 ָ vERO/Hslam ǿ ״. ̹ ƾ ߴ. 
, ̹ ƾ û׿ 24ð ̳ RNA ̷ 93% ƴ. ̷ 99.8% Ÿ. 
48ð ̹ ƾ ġ RNA ̷ 5000 پ. 72ð ̷ ̻ ʾҴ. ƴ. 
"ٸ RNA ̷ ϰ IMP/1 Ű ټ(nuclear import)Ǵ ̷ ܹ ν ̹ƾ ȿ ִٴ " ߴ. 
ġ ۿ?
̹ ƾ ó ϰų Ǻο ٸ ִ. 뷮 ġϴ ޶ ๰ ĸ ϸ ̻ Ͼ ִ. 
ۿ , , , , ޽, ִ. 
ǰǾǰó ̹ ƾ ʾ "Ϲ ⿡ ġ ߵǷ ӻ ߰ ʿϴ" . 


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